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KMID : 0359720180360040354
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Journal of the Korean Neurological Association
2018 Volume.36 No. 4 p.354 ~ p.357
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Bilateral Lesions in the Posterior Limb of Internal Capsule Attributed to Combination Therapy of Isoniazid and Rifampin
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Park Min-Won
Roh Jin-Hong
Im Seo-Jun
Kim Min-Ok
Kim Young-Soo
Kang Jong-Soo
Kim Do-Hyung
Kwon Oh-Young
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Abstract
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Transient isoniazid-induced brain lesions have rarely been reported. The lesions were in the dentate nucleus of cerebellum and thalamus. Meanwhile, the neurotoxicity of rifampin has not been reported evidently. We observed bilateral lesions in the internal capsule in a young woman after taking a combination of isoniazid and rifampin. She transiently suffered numbness in both hands, dysarthria, and left side motor weakness while taking the medication. Isoniazid may induce structural lesions in various brain areas including the internal capsule.
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KEYWORD
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Isoniazid, Neurotoxicity syndromes, Internal capsule
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